For centuries, it was theorized that Francesco I de' Medici, Grand Duke of Tuscany, and his second wife, Bianca Cappello were murdered, but new evidence shows that their deaths were from natural causes.
The bodies of the Flroentine couple were recently exhumed, and the cause of death has been resolved: malaria.
"It appears it wasn't poison. We carried an immunologic investigation and found evidence of the protozoan parasite Plasmodium falciparum. ... We are talking of the most deadly of the Plasmodium species that cause malaria," Gino Fornaciari, professor of forensic anthropology and director of the Pathology Museum at the University of Pisa, told Discovery News.