The painting entitled "Old Woman," but better known as the "Ugly Duchess," is one of the most popular in London's National Gallery. It depicts the face of a grotesquely-featured woman, and was painted by Flemish artist Quinten Massys in 1513. Now, experts believe that they have identified the illness suffered by this woman as a rare form of Paget's disease, which deforms the bones. (photo)
The portrait, either inspired by or copied by Da Vinci, is a centerpiece of the museum's Renaissance Faces: Van Eyck to Titian exhibit which runs October 15, 2008-January 18, 2009. It is also supposed to be the inspiration for Lewis Carroll's Alice illustrator John Tenniel's creation of the Duchess.